FOXP3 anticorps (Elab Fluor®700)

N° du produit ABIN7566959

L’anticorps Souris Monoclonal anti-FOXP3 a été validé pour FACS. Il convient pour détecter FOXP3 dans des échantillons de Souris.

Aperçu rapide pour FOXP3 anticorps (Elab Fluor®700) (ABIN7566959)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est conjugé à/à la Elab Fluor®700

Application: Flow Cytometry (FACS)

Clone: 3G3

Détail du produit anti-FOXP3 anticorps (Elab Fluor®700)

Fonction: Elab Fluor®700 Anti-Mouse Foxp3 Antibody[3G3]

Isotype: IgG1, kappa

Information d'application

Indications d'application: Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.

Commentaires:

Matching Isotype Control: E-AB-F09792M1

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Stock: 4 °C

Stockage commentaire: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Date de péremption: 12 months

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: Foxp3

Sujet: Forkhead box protein P3,Foxp3,IPEX,JM2,Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence, the other (Foxp3 δ2) lacking exon 2.

ID gène: 50943, 20371, 317382

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation